5 hours ago · Monday Night Football closes out Week 16 with a huge matchup between the San Francisco 49ers and the Indianapolis Colts. Both teams are fighting to keep pace in the …

Live coverage of the San Francisco 49ers vs. Indianapolis Colts NFL game on ESPN, including live score, highlights and updated stats.

9 hours ago · 49ers vs. Colts — Latest Week 16's edition of "Monday Night Football" features the San Francisco 49ers traveling to Indianapolis to face Philip Rivers and the Colts.

18 hours ago · Get the best 49ers vs. Colts predictions and odds ahead of Week 16 Monday Night Football on December 22, 2025. Take the Over.

15 hours ago · Colts vs. 49ers prediction: Indianapolis and San Francisco do battle with playoff positioning on the line The Niners control their own destiny in the NFC, while the Colts need …

1 day ago · The Indianapolis Colts host the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Live score updates, highlights, where to watch.

1 day ago · 49ers vs. Colts MNF prediction: Odds, expert picks, QB matchup, injury update, betting trends, and stats By Rotoworld Bet Staff Published December 21, 2025 06:53 PM

4 hours ago · The San Francisco 49ers visit the Indianapolis Colts in Week 16 of the NFL season. Follow along for highlights and live score updates.

1 day ago · NFL.com's Bobby Kownack breaks down three must-know storylines ahead of Week 16's prime-time game between the San Francisco 49ers and Indianapolis Colts.

14 hours ago · The San Francisco 49ers are back in primetime for their Week 16 contest against the Indianapolis Colts. The team released the final injury report ahead of the "Monday Night …