Luche reduction is the selective organic reduction of α,β-unsaturated ketones to allylic alcohols. [1][2][3] The active reductant is described as "cerium borohydride", which is generated in situ …

Mechanism of the Luche Reduction CeCl 3 is a selective Lewis acid catalyst for the methanolysis of sodium borohydride. The resulting reagents, various sodium methoxyborohydrides, are …

Mar 2, 2011 · Luche reduction of a chroman-4-one is used during the synthesis of antagonists of leukotrine D4 <1998BML1791>. The reaction of ethylene and 3-methoxy-2-methylchromen-4 …

The Luche reduction is an organic reaction used to convert an α,β-unsaturated ketone to an allylic alcohol using cerium trichloride, sodium borohydride, and an alcohol solvent.

The Luche reduction is a regioselective reduction to afford allyl alcohols from α,β-unsaturated ketones. When α,β-unsaturated ketones are reduced with sodium borohydride (NaBH 4), 1,4 …

Mar 27, 2014 · In the substrate containing both ketone and aldehyde groups, Ce (III)-catalyzed acetalization (or hemiacetalization or hydration) prevents the aldehyde from getting reduced, …

Luche reduction is the selective organic reduction of α,β-unsaturated ketones to allylic alcohols. The active reductant is described as "cerium borohydride", which is generated in situ from …

What is the Luche Reduction? It is a specific type of highly regioselective reduction that results in a 1,2 reduction of ketones, aldehydes, or enones. What are the conditions required for this …

Methods to selectively reduce the ketone (Luche Reduction) and the alkene (Stryker Reduction) have been developed. Reductions of aldehydes and ketones follow the same selectivity …

Significance: In 1978, Luche reported the selec-tive 1,2-reduction of , -unsaturated ketones by using sodium borohydride in the presence of vari-ous lanthanide chlorides, leading to allylic …