A double-strand break repair model refers to the various models of pathways that cells undertake to repair double-strand breaks (DSB). DSB repair is an important cellular process, as the …

The result is double-strand breaks (DSBs) in the chromosome. A DSB can also be caused by environmental exposure to irradiation, other chemical agents, or ultraviolet light (UV).

Double-stranded breaks are one of the most harmful forms of DNA damage that cells can sustain. They are characterized by breakage of the sugar-phosphate backbone on opposing strands of …

A double stranded DNA break is defined as a form of genomic disruption that involves breaks in both strands of DNA at a specific site, which can activate checkpoint responses and lead to …

Jul 28, 2025 · Among the many types of DNA damage, a double strand break is a significant form. This damage involves the complete severance of both strands of the DNA helix, posing a …

Oct 6, 2023 · A wide variety of DNA damage types have been described, but double-strand breaks (DSBs) stand out as one of the most toxic DNA lesions. Two major pathways account …

Double-strand break (DSB), a significant DNA damage brought on by ionizing radiation, acts as an initiating signal in tumor radiotherapy, causing cancer cells death.

Mar 14, 2023 · In meiosis, the SPO11 nuclease creates double-strand breaks that allow homologous recombination, in which DNA is shuffled between chromosomes, creating genetic …

Dec 3, 2025 · LA JOLLA, CA— The DNA inside our cells is constantly being damaged, and one of the worst kinds of damage is a double-strand break—when both sides of the DNA helix are cut …

Learn about double-strand break repair, including what causes double- and single-strand breaks in DNA. Review repair mechanisms for DNA double-strand breaks.