Apr 1, 2024 · Rac1 is a member of the Rho GTPase family which plays major roles in cell mobility, polarity and migration, as a fundamental regulator of actin cytoskeleton.

Four different Rac proteins have been described to date: Rac1, Rac2, Rac3, and RhoG. Rac1 is ubiquitously expressed by many different cell types and can be found in several tissues …

Sep 1, 2022 · Rac1 is a ubiquitous protein but frequently overexpressed and/or hyperactivated in cancer cells. A few potent inhibitors of Rac1 display marked antitumor effects in experimental …

Understanding the role and the regulatory mechanism of Rac1 in cell migration can provide fundamental insights into Rac1-related cancer progression and further help us to develop …

Jul 1, 2024 · Rac1 regulates monocyte adhesion and migration via activation of Pyk2 and p38MAPK.

Apr 11, 2024 · Switch I region mutations also variably increase RAC2 binding to its downstream effector P21 (RAC1) activated kinase 1 (PAK1), which regulates cytoskeleton remodeling and …

Oct 21, 2022 · We found that RAC1 is a driver of growth and innate drug resistance to BRAFi in some melanoma cell lines and that the reliance on RAC1 was associated with the de …

Este trabajo identifica los mecanismos moleculares que regulaban el transporte de Rac1 entre el núcleo y el citoplasma. Una vez en el núcleo, Rac1 promueve cambios en la estructura del …

Jul 15, 2022 · We show that the actin cytoskeleton is dynamically associated with endoA3- and CD166-positive endocytic carriers, and that its perturbation strongly inhibits the process of …

May 17, 2021 · Rac1 inhibitors play a role by blocking the activation of Rac1 by guanine nucleotide factor, the upstream effector of Rac1. This figure also shows the effect of the …