The renin-angiotensin system (RAS) remains a cornerstone of cardiovascular and renal physiology, orchestrating vital aspects of blood pressure regulation and fluid-electrolyte balance. At the heart of ...

Renin–angiotensin system (RAS) inhibitors — including angiotensin-converting–enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) — slow the progression of mild or moderate chronic kidney ...

Jennifer M. Jones, Jung-Jun Park, Jennifer Johnson, Dave Vizcaino, Brian Hand, Robert Ferrell, Matthew Weir, Thomas Dowling, Thomas Obisesan, Michael Brown https ...

The scientists discovered that the hormone angiotensin II, also known as ang II, helps control renin by affecting calcium ...

In this first-in-human, placebo-controlled study, patients who received zilebesiran showed dose-dependent decreases in serum angiotensinogen levels and 24-hour ambulatory BP after a single ...

Testing for aldosterone levels may hold the key to treatment-resistant hypertension and many other cardiac conditions, but ...

A new study has identified a critical "pressure sensor" inside the kidney that helps the body control blood pressure and ...

We have identified human cultured cell lines that are useful for studying angiotensinogen gene expression and its regulation in the central nervous system. A model cell system of human central nervous ...

Credit: Getty Images. The drug, which interferes with RNA to reduce production of angiotensinogen, could make it possible to treat hypertension with quarterly or twice yearly subcutaneous ...

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, announced today that it is broadening its pipeline with ALN-AGT, a subcutaneously ...