This isn’t the first time Polis, who is seen as a possible 2028 Democratic presidential contender, has shown a willingness to butt heads with his party.

President-elect Trump's decision to tap Robert F. Kennedy Jr as his nominee for secretary of Health and Human Services has elicited mixed reactions from Republicans on Capitol Hill. Why it matters: Kennedy — an anti-vaccine activist who previously ran against Trump for president before dropping out and endorsing him — will need to lock down support from key senators to get through the conformation process.