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PI3K/AKT/mTOR pathway, hypoxia, and glucose metabolism: Potential targets to overcome radioresistance in small cell lung cancer

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BioWorld

Optimized mTOR inhibitor has potent antiproliferative activity

Dysregulation of the mechanistic target of rapamycin (mTOR) signaling pathway is frequently observed across a wide range of cancers and contributes to uncontrolled cell proliferation, enhanced ...
ascopubs.org

Effect of EGR1-mediated glutamine metabolic reprogramming through mTOR signaling pathway on pancreatic stellate cell activation and pancreatic cancer liver metastasis.

Potent antitumor activity of the KRASG12D inhibitor MRTX1133 in pancreatic cancer: Augmenting the nanoparticle-paclitaxel chemotherapy response. This is an ASCO Meeting Abstract from the 2025 ASCO ...
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DDAH1 controls hepatic lipid metabolism under fasting

DDAH1 plays a critical role in hepatic lipid metabolism under fasting conditions by modulating FABP1 expression and AMPK/mTOR-mediated autophagy. The liver plays a central role in maintaining systemic ...