Vaccinations have revolutionized healthcare, but designing them remains complex, requiring time and creativity, especially for vaccines against viruses, which are difficult to study. “Each virus ...
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Massively parallel profiling reveals thousands of hidden viral proteins and conserved mechanisms
These elusive sequences are known to impact viral replication, host immune responses, and gene regulation, yet their detection requires experimental methods beyond current computational tools.
The RNA profiling core provides access to expertise and infrastructure for advanced transcriptomic profiling approaches, including Ribosome Profiling (mapping of translating ribosomes), CLIP (mapping ...
This study illustrates how persistent mRNA rG4 structures induce ribosome pausing and collisions, leading to proteostasis collapse in senescent cells. The RNA helicase DHX9 acts as a key regulator, ...
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