The equipoise randomization strategy allowed patients to indicate a preference to which of the level 2 options they would accept or refuse. Only 1% of the cohort would accept all 7 treatment options.

The quality and safety of a biopharmaceutical is determined by how well its manufacture is controlled. The challenge is that the modeling methods used to develop control strategies sometimes struggle ...

The genetic and clinical heterogeneity of breast cancer makes the identification of effective therapies challenging. We designed I-SPY 2, a phase 2, multicenter, adaptively randomized trial to screen ...