Cancers driven by hiccups in RNA processing can’t hide from our immune system, according to new work published today in Cell. A cross-institutional team Fred Hutch Cancer Center and Memorial Sloan ...
A University of California, Irvine-led research team has discovered intricate molecular mechanisms driving the RNA processing defects that lead to Huntington's disease and link HD with other ...
Chloroplast gene expression is governed by a sophisticated network of nuclear‐ and plastid‐encoded factors that integrate transcription, RNA processing and translation. Central to this process is the ...
The IDR in TAF2 steers the protein away from active gene promoters, where it participates in transcription initiation, to nuclear speckles — liquid-like compartments that concentrate factors for RNA ...
v. 1. Synthesis and purification of RNA substrates / Benoit Chabot -- Characterization of RNA / Paula J. Grabowski -- Splicing of mRNA precursors in mammalian cells / Ian C. Eperon, Adrian R. Krainer ...
To build proteins, cells rely on a molecule called transfer RNA, or tRNA. tRNAs act like protein-building couriers, where they read the genetic instructions from messenger RNA, mRNA, and deliver the ...
RNA-binding proteins (RBPs) are central regulators of post-transcriptional gene expression. They modulate key aspects of mRNA metabolism—such as splicing, ...
The use of RNA is a promising approach for a growing range of therapeutics and vaccines, but overcoming a few challenges would enable it even further. Stability and persistence in the body are ...
Ion-pairing reversed-phase liquid chromatography (IP-RPLC), a standard method to characterize small oligonucleotides, can also separate large RNA molecules. Its advantages extend beyond simple ...
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