Listen with Speechify 0:00 1:00 by Lewis Cantley Click on the enzyme names or on the the arrows to follow the PIP pathway. Please download the Adobe Flash Player to view this content: From Kinase to ...

The PI3K/PDK1/Akt signaling axis is centrally involved in cellular homeostasis and controls cell growth and proliferation. Due to its key function as regulator of cell survival and metabolism, the ...

Phosphatidylinositol 3-kinase (PI 3K) acts upstream of myriad cellular pathways, including those that regulate protein synthesis and tumorigenesis. In this example, PI 3K phosphorylates the lipid PI ...

An agreed PIP is the regulatory pathway to market authorization for leniolisib as a treatment of activated phosphoinositide 3-kinase delta syndrome in children Leiden, The Netherlands, 06 January, ...