Kickoff from Lucas Oil Stadium is set for 1 p.m. ET. Jacksonville is a 6.5-point favorite in the latest Jaguars vs. Colts odds at DraftKings, and the total comes in at 48.5. Before making any Colts vs. Jaguars picks of your own, make sure to look at the top NFL picks from the SportsLine Projection Model, which simulates every NFL game 10,000 times.

Each week Jeff Schudel makes his NFL picks against the Las Vegas betting line while picking the Browns score separately. Picks are in bold letters. Last week: 6-6-1. Overall: 107-110-3. Browns vs.

One of the hottest teams in the NFL right now, led by their No.1 defense, kicks off the Saturday action. C.J. Stroud and the Houston Texans travel to face the Los Angeles Chargers. Both teams are fighting for AFC positioning, making every possession feel like January football.

Chris Vasile breaks down his favorite NFL picks against the spread for Week 15, including the Los Angeles Rams and Denver Broncos.

Look for the Panthers and Seahawks to win major NFC battles against division leaders, and for the Niners to get their 11th win.