In a rapid communication published in the journal Genes & Diseases, has shed light on the role of the Wnt signaling pathway in influencing the immune response of colorectal cancer (CRC) patients.
The Dako Omnis test identifies mismatch repair deficient colorectal cancer patients eligible for Opdivo or Opdivo plus Yervoy treatment. Mismatch repair deficiency results in DNA replication errors, ...
I. Platinum-based therapies induce DNA inter-strand crosslinks (ICLs), which exacerbate genomic instability and impede DNA replication. In BRCA1/2-deficient tumor cells, the repair of these DNA ...
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