At last, the researchers have defined the molecular basis of the cell membrane in integrin activation. Scripps Research scientists have uncovered the workings of a critical process in cell survival.

Efficacy of newly developed platinum complexes against osteosarcoma, bone-targeting platinum, and proteasome inhibitory platinum. This is an ASCO Meeting Abstract from the 2012 ASCO Annual Meeting I.

Scientists at City of Hope ®, one of the largest cancer research and treatment organizations in the United States, have discovered a new cellular mechanism that plays an important role in cancer cells ...

Phagocytosis by monocytes or neutrophils can be enhanced by interaction with several proteins or synthetic peptides containing the Arg-Gly-Asp sequence. Recently we showed that an mAb, B6H12, ...

Cells sense multiple environmental signals through their matrix adhesion complexes, mediated via integrin receptors. These adhesions enable cells to behave differently on 2- and 3-dimensional matrices ...

Protein surface (left) and ribbon (right) models of integrin αV's β-propeller domain illustrate the capacity of Cpd_AV2 (yellow) in disrupting the interaction between integrin β5's βA loop (cyan; ...

Integrin-associated protein (IAP), CD47, was first found in research that focused on integrin αvβ3. This research found that CD47 was to be associated in cis with integrin αvβ3 on the cell membrane.

Focal adhesions (FAs) are essential structures for cell adhesion, migration, and morphogenesis. Integrin-linked kinase (ILK), which is capable of interacting with the cytoplasmic domain of β1 integrin ...

The tissue in our body can only hold together if the cells adhere not only to each other, but also to extracellular structures, such as collagen fibers of the connective tissue and the skin. How ...