The idea that centrosome aberrations could drive tumour development was proposed more than 100 years ago and yet there is still uncertainty as to whether extra centrosomes are a cause or a consequence ...

When a cell is dividing, two identical structures, called centrosomes, move to opposite sides of the cell to help separate its chromosomes into the new cells. More than 100 years ago, scientists ...

For almost a century, our understanding of the tiny structure at the centre of the cell called the centrosome was limited to its ability to organize mitotic spindles and other microtubule arrays.

R. Basto et al., “Centrosome amplification can initiate tumorigenesis in flies,” Cell, 133:1032–42, 2008. (Cited in 32 papers) Tumor cells display both chromosomal instability and centrosome ...

Centrosomes are in fact not "one type fits all" In close collaboration with the Helmholtz Munich Proteomic Core Facility led by Stefanie Hauck, the researchers found that the composition of proteins ...

During cell division, centrosomes help properly distribute chromosomes. When chromosome distribution goes wrong, each new cell inherits either too many or too few chromosomes. Holland says the ...

When cells extend, move, or divide, a tiny organelle called the centrosome provides a cytoskeletal anchor and regulatory hub. It was long held that centrosomes are similar in composition across cells.

The paper M.S. Levine et al., “Centrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals,” Dev Cell, 40:313-22, 2017. Three’s a crowd More than a century ago, the German ...

Unlike many of us during the COVID-19 pandemic, biological cells are not isolated from the outside world. Chemical variations, intercellular activity, and other microenvironmental factors impact cell ...

This is a preview. Log in through your library . Abstract Adult stem cells often divide asymmetrically to produce one self-renewed stem cell and one differentiating cell, thus maintaining both ...

When a cell is dividing, two identical structures, called centrosomes, move to opposite sides of the cell to help separate its chromosomes into the new cells. When a cell is dividing, two identical ...

The centrosome is the organelle responsible for the organization of the cytoskeleton during cell division, an essential function in organisms from yeast to humans. Until now, scientists assumed that ...