A team led by scientists has come a step closer to uncovering the purpose of a distinctive set of modifications found at the beginning of messenger RNA which have long remained a fundamental mystery ...

Researchers have discovered that a chemical modification to the synthetic messenger RNA used in therapeutics can cause the cell’s machinery to misread its instructions and result in unintended immune ...

Researchers have incorporated a base into mRNA that is not naturally present in the human body, producing mRNA that has decreased cytotoxicity compared to unmodified mRNA. Modified mRNA is more stable ...

In a recent review published in Nature Medicine, researchers presented challenges related to the clinical translation of messenger ribonucleic acid (mRNA) technology, recent innovations, and future ...

Hepatitis C virus (HCV) infections are associated with the risk of progression to fibrosis, cirrhosis, and hepatocellular carcinoma. The HCV RNA genome is translated by an internal ribosome entry site ...

Their specific structure at the beginning of the chain, called a cap, has two main functions. It protects the mRNA from breaking down, but also it plays a key role in the way the messenger RNA ...