Mushroom compounds (e.g., Ganoderic Acid DM, Cordycepin) modulate autophagy via phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mechanistic target of rapamycin (mTOR), AMP-activated protein ...
ErbB Receptor Feedback Inhibitor 1 Mutation in Biliary Tract Cancers: Turning Resistance Into Response Short-term intervention studies in KPC mice and a phase I clinical trial based on a time-to-event ...
ImmuPharma PLC (AIM:IMM, FRA:25I), the specialist drug discovery and development company, has highlighted new research into ...
In a twist that blurs the lines between two devastating diseases, scientists have spotted dementia-like behavior in the pancreas. In mice, pancreatic cells teetering on the brink of cancer began to ...
A research team has discovered a novel mechanism essential for initiating autophagy. The study highlights the role of ZDHHC13, an enzyme that palmitoylates ULK1, in triggering autophagy. This ...
A new study unravels the relationship between mitofusins (mitochondrial proteins) and autophagy. Using gene editing with CRISPR-Cas9, the team has been able to study these proteins without altering ...
Researchers at Karolinska Institutet, led by Dr. Helin Norberg and Dr. Erik Norberg, have identified a previously unknown mechanism that affects the ability of cancer cells to spread in the body. The ...
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